2,4-Dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine
Fmoc-2,4-Dichloro-L-phenylalanine
CAS: 352351-62-3
Molecular Formula: C24H19Cl2NO4
2,4-Dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine - Names and Identifiers
| Name | Fmoc-2,4-Dichloro-L-phenylalanine |
| Synonyms | RARECHEM BK PT 0111 FMOC-PHE(2,4-CL 2)-OH FMOC-PHE(2,4-DICL)-OH Fmoc-L-2,4-Dichlorophe FMOC-L-PHE(2,4-CL2)-OH FMOC-L-2,4-DICHLOROPHE FMOC-L-2,4-DICHLOROPHENYLALANINE Fmoc-2,4-Dichloro-L-phenylalanine FMOC-2,4-DICHLORO-L-PHENYLALANINE 2,4-dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine 2,4-Dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine L-phenylalanine, 2,4-dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]- (S)-3-(2,4-DICHLORO-PHENYL)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PROPIONIC ACID (2S)-3-(2,4-Dichlorophenyl)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoic acid |
| CAS | 352351-62-3 |
| InChI | InChI=1/C24H19Cl2NO4/c25-15-10-9-14(21(26)12-15)11-22(23(28)29)27-24(30)31-13-20-18-7-3-1-5-16(18)17-6-2-4-8-19(17)20/h1-10,12,20,22H,11,13H2,(H,27,30)(H,28,29)/t22-/m0/s1 |
2,4-Dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine - Physico-chemical Properties
| Molecular Formula | C24H19Cl2NO4 |
| Molar Mass | 456.32 |
| Density | 1.394±0.06 g/cm3(Predicted) |
| Boling Point | 659.9±55.0 °C(Predicted) |
| Flash Point | 352.9°C |
| Vapor Presure | 2.59E-18mmHg at 25°C |
| pKa | 3.67±0.12(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.641 |
2,4-Dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
2,4-Dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine - Introduction
Fmoc-2,4-Dichloro-L-phenylalanine is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: White or off-white solid
-Molecular formula: C20H15Cl2NO4
-Molecular weight: 412.24g/mol
-Melting point: 153-157 degrees Celsius
-Solubility: Soluble in chloroform, dichloromethane, acetone and other organic solvents, insoluble in water.
Use:
- Fmoc-2,4-Dichloro-L-phenylalanine is a commonly used amino acid protecting group. It is often used in peptide synthesis as a protecting group for amino acids, which can be protected by reacting the dichlorophenyl structure on the aromatic nucleus with the amino group in the amino acid.
-It can also be used for other purposes in organic synthesis, such as the synthesis of small molecules.
Preparation Method:
- Fmoc-2, the preparation method of 4-Dichloro-L-phenylalanine is more complicated, and generally requires the use of organic synthesis methods to synthesize.
-The main synthesis method includes the reaction of chlorobenzyl magnesium chloride with 2,4-dichlorophenyl sulfate to obtain the corresponding 2,4-dichlorophenyl propanol, and then react with L-phenylalanine to generate Fmoc-2,4-Dichloro-L-phenylalanine.
Safety Information:
- Fmoc-2,4-Dichloro-L-phenylalanine is a chemical and needs to be handled in accordance with relevant safety practices.
-When using, avoid direct contact with skin and eyes, and avoid inhaling its dust or solution. Wear protective gloves, safety glasses and protective mask when necessary.
-It should be kept in a dry, cool place away from direct sunlight.
-For specific safety information and toxicological data, it is recommended to refer to the safety data sheet (SDS) of the compound or consult a professional.
Nature:
-Appearance: White or off-white solid
-Molecular formula: C20H15Cl2NO4
-Molecular weight: 412.24g/mol
-Melting point: 153-157 degrees Celsius
-Solubility: Soluble in chloroform, dichloromethane, acetone and other organic solvents, insoluble in water.
Use:
- Fmoc-2,4-Dichloro-L-phenylalanine is a commonly used amino acid protecting group. It is often used in peptide synthesis as a protecting group for amino acids, which can be protected by reacting the dichlorophenyl structure on the aromatic nucleus with the amino group in the amino acid.
-It can also be used for other purposes in organic synthesis, such as the synthesis of small molecules.
Preparation Method:
- Fmoc-2, the preparation method of 4-Dichloro-L-phenylalanine is more complicated, and generally requires the use of organic synthesis methods to synthesize.
-The main synthesis method includes the reaction of chlorobenzyl magnesium chloride with 2,4-dichlorophenyl sulfate to obtain the corresponding 2,4-dichlorophenyl propanol, and then react with L-phenylalanine to generate Fmoc-2,4-Dichloro-L-phenylalanine.
Safety Information:
- Fmoc-2,4-Dichloro-L-phenylalanine is a chemical and needs to be handled in accordance with relevant safety practices.
-When using, avoid direct contact with skin and eyes, and avoid inhaling its dust or solution. Wear protective gloves, safety glasses and protective mask when necessary.
-It should be kept in a dry, cool place away from direct sunlight.
-For specific safety information and toxicological data, it is recommended to refer to the safety data sheet (SDS) of the compound or consult a professional.
Last Update：2024-04-10 22:29:15
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View History
2,4-Dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine
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